The strategy is based on the hypothesis that beneficial as well as maladaptive forms of hypertrophy exist and that heart failure is frequently preceded by maladaptive hypertrophy (Figure 1). We will dissect both adaptive and maladaptive signalling in hypertrophy to identify beneficial and maladaptive components of signal transduction in hypertrophy and heart failure.
 
Signalling in hypertrophy and heart failure and the EUGeneHeart approach.

The EUGeneHeart consortium forms an extremely integrated project comprised of six major tasks.

 
Project goal of EUGeneHeart
The ultimate accomplishment will include improvement of health, reduction of health expenses, as well as creation of new jobs and economic benefit.